Srila Prabhupada träffade sin andlige mästare Srila Bhaktisiddhanta Sarasvati 1922. Denne bad då Srila Prabhupada att sprida den vediska kunskapen på engelska. Under åren som följde skrev Srila Prabhupada en kommentar till Bhagavad-gita och bistod Gaudiya Matha i dess arbete. År 1944 började han ge ut Back to Godhead, en tidskrift på engelska som kom ut varannan vecka.
Renunciation Through Wisdom is a collection of essays originally written in Bengali and published by Srila Prabhupada in India during the 1940s. They were later translated into English by his disciples.
In these essays Srila Prabhupada expands on themes found in the Bhagavad-gita, discussing such topics as why people are averse to God, the ultimate causes of suffering, and how the world’s troubles are extraordinarily fleeting when seen from the standpoint of eternity.
Students of Srila Prabhupada will recognize the same common-sense writing style in Renunciation Through Wisdom as in his later, well-known works such as Srimad-Bhagavatam and Bhagavad-gita As It Is, as well as his expertise at distilling the essence of India's ancient Vedic wisdom into powerful, convincing, practical, and easily readable directives.