Srila Prabhupada träffade sin andlige mästare Srila Bhaktisiddhanta Sarasvati 1922. Denne bad då Srila Prabhupada att sprida den vediska kunskapen på engelska. Under åren som följde skrev Srila Prabhupada en kommentar till Bhagavad-gita och bistod Gaudiya Matha i dess arbete. År 1944 började han ge ut Back to Godhead, en tidskrift på engelska som kom ut varannan vecka.
Srila Prabhupada wrote Message of Godhead in the 1950s, while still living at the Radha-Damodara temple in Vrindavan, India. It was one of his first book-length manuscripts, yet wasn't discovered until years after he had come to the West. It was first published in 1991. Through vivid examples Prabhupada makes the case that there's much more to reality than what our senses can perceive. Message of Godhead is one of Srila Prabhupada's slimmest written volumes, yet it stands as a compelling, comprehensive introduction to all the major points of Krishna conscious philosophy, which he explains in much greater detail in his Bhagavad-gita As It Is and Srimad-Bhagavatam.