Srila Prabhupada träffade sin andlige mästare Srila Bhaktisiddhanta Sarasvati 1922. Denne bad då Srila Prabhupada att sprida den vediska kunskapen på engelska. Under åren som följde skrev Srila Prabhupada en kommentar till Bhagavad-gita och bistod Gaudiya Matha i dess arbete. År 1944 började han ge ut Back to Godhead, en tidskrift på engelska som kom ut varannan vecka.
Srimad-Bhagavatam, an epic philosophical and literary classic, holds a prominent position in India's voluminous written wisdom. The timeless wisdom of India is expressed in the Vedas, ancient Sanskrit texts that touches upon all fields of human knowledge. Originally preserved through oral tradition, the Vedas were first put into writing by Srila Vyasadeva, the "literary incarnation of God." After compiling the Vedas, Srila Vyasadeva was inspired by his spiritual master to present their profound essence in the form of Srimad-Bhagavatam. Known as "the ripened fruit of the tree of Vedic literature," Srimad-Bhagavatam is the most complete and authoritative exposition of Vedic knowledge.
After writing the Bhagavatam, Vyasa taught it to his son, Shukadeva Goswami, who later spoke the Bhagavatam to Maharaja Parikshit in an assembly of sages on the bank of the sacred Ganges River. Although Maharaja Parikshit was a great rajarshi (saintly king) and the emperor of the world, when he received notice of his death seven days in advance, he renounced his entire kingdom and retired to the bank of the Ganges to seek spiritual enlightenment. The questions of King Parikshit and Shukadeva Goswami's illuminating answers, concerning everything from the nature of the self to the origin of the universe, are the basis of Srimad-Bhagavatam.